Haematological variations and plasma volume changes in elite race walkers: the effects of altitude and tapering

Code: 22D02RF

The goal of our research is to investigate the impact of altitude training on blood values in elite athletes preparing for a major competition, with special focus on the biomarkers considered in the framework of the Athlete Biological Passport (ABP). Testing the hypothesis that hypoxic training is related to hematological variations would allow the present ABP model to be refined, and its efficacy strengthened. Our study would challenge the complexity of confounding factors affecting the interpretation of the ABP in elite athletes. In addition, based on the current development of a multi-parametric model previously validated in elite cyclists to compare inferred and actual plasma volume (PV) variations, investigation of the potential confounding effects of altitude exposure, and pre-competition tapering phase, can provide additional experimental evidence towards future improvements of the ABP.

The main objectives of this study are the following: firstly, this study will allow to further investigate the hematological variables of the ABP before, during, after a 3-week altitude training camp and on days before and after a major competition (20 days after the return to see level); furthermore, the potential confounding effect of hypoxic exposure will be evaluated by measuring PV changes or inferring the latter changes from serum biomarkers that are sensitive to PV changes. Overall, our study aims at improving the ABP in its current form and at evaluating the possible implementation of additional biomarkers.